Reacción #9680

Ecuación de reacción

ammonium hydroxide

N-(4-iodophenyl)-N′-(4-methylphenyl) thiourea

bromine

sulphurous acid

→

N-(4-iodophenyl)-6-methyl-1,3-benzothiazol-2-amine

Rendimiento 97.0%

Disolventes

chloroform

chloroform

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated at 50° C. for 5 minutes
2. 2
   Temperaturato cool
3. 3
   workup.DISSOLUTIONto dissolve the precipitate
4. 4
   OtroThe layers was separated
5. 5
   Lavadothe organic layer was washed with water and brine
6. 6
   Secadodried over sodium sulfate
7. 7
   Filtraciónfiltered
8. 8
   Concentraciónconcentrated

Procedimiento

A suspension of N-(4-iodophenyl)-N′-(4-methylphenyl) thiourea (0.62 g, 4.68 mmol) in chloroform (23 mL) was treated with a solution of bromine (2.65 g, 16.59 mmol) in chloroform (1 mL). The reaction mixture was stirred at rt for 5 minutes and then heated at 50° C. for 5 minutes. Then the reaction mixture was allowed to cool, and was treated with sulphurous acid until the orange color disappeared. The reaction mixture was neutralized by treatment with conc. ammonium hydroxide. More chloroform was then added to dissolve the precipitate. The layers was separated, and the organic layer was washed with water and brine, dried over sodium sulfate, filtered and, concentrated to give N-(4-iodophenyl)-6-methyl-1,3-benzothiazol-2-amine (0.6 g, 97%). 1H NMR (400 MHz, DMSO-d6) δ 2.36 (s, 3H), 7.12 (m, 1H), 7.48 (d, 1H), 7.60 (m, 3H), 7.65 (m, 2H), 10.50 (s, 1H).

Fuente