Reacción #963810

Ecuación de reacción

2-iodophenol

3-hydroxy-3-methylbutyl tosylate

Cs2CO3

→

4-(2-iodophenoxy)-2-methylbutan-2-ol

Disolventes

DMF

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with 1N HCl, saturated NaHCO3 aq., H2O, and brine
2. 2
   Secadodried over anhydrous Na2SO4
3. 3
   OtroThe solvent was removed under reduced pressure
4. 4
   OtroThe resulting residue was purified by silica gel column chromatography (Hexane/EtOAc=7/3)
5. 5
   Otroto obtain compound aa28-1 (8.02 g) as pale yellow oil

Procedimiento

A mixture of 2-iodophenol (6 g), 3-hydroxy-3-methylbutyl tosylate (7.4 g) and Cs2CO3 (13.3 g) in DMF (120 mL) was stirred at 0° C. for 2 h and at room temperature for 10 h. The mixture was diluted with EtOAc and washed with 1N HCl, saturated NaHCO3 aq., H2O, and brine, and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (Hexane/EtOAc=7/3) to obtain compound aa28-1 (8.02 g) as pale yellow oil.

Fuente