Reacción #962

Ecuación de reacción

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

sodium cyanide

Water

→

product

Rendimiento 92.0%

(3RS)-1-benzyl-3-cyanomethyl pyrrolidine

Rendimiento 92.0%

Disolventes

dimethyl sulfoxide

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture was extracted three times with ethyl acetate
2. 2
   LavadoThe combined organic layer was washed with brine
3. 3
   Secadodried (Na2SO4)
4. 4
   Filtraciónfiltered
5. 5
   Otroevaporated

Procedimiento

16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.

Fuente