Reacción #96192

Ecuación de reacción

4-Aminobutanol

N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea

→

title compound

Rendimiento 38.6%

N-Cyano-N'-(4-hydroxybutyl)-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine

Rendimiento 38.6%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mixture was evaporated
2. 2
   Otroto yield an oil which
3. 3
   Otrowas chromatographed on a silica gel column
4. 4
   Lavadoeluted with chloroform and chloroform/methanol (20:1)

Procedimiento

4-Aminobutanol (2.7 g) and N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (4.05 g) were refluxed in ethanol (30 ml) for 4 hours. The reaction mixture was evaporated to yield an oil which was chromatographed on a silica gel column and eluted with chloroform and chloroform/methanol (20:1) to give the title compound as a colourless oil (1.8 g).

Fuente