Reacción #96145

Ecuación de reacción

ethyl 3-(chloro-4-cyanophenyl)propanoate

KOH

→

3-(2-chloro-4-cyanophenyl)propanoic acid

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroevaporated to dryness
2. 2
   workup.DISSOLUTIONThe residue was dissolved in 5% NaHCO3
3. 3
   Lavadowashed with EtOAc
4. 4
   FiltraciónAcidification and filtration

Procedimiento

A mixture of ethyl 3-(chloro-4-cyanophenyl)propanoate (33.0 g, 0.14 mol), KOH (6.27 g, 0.11 mol) and 95% ethanol (109 mL) was warmed at 40° C. for 1 h. The mixture was neutralized and evaporated to dryness. The residue was dissolved in 5% NaHCO3 and washed with EtOAc. Acidification and filtration gave crystalline 3-(2-chloro-4-cyanophenyl)propanoic acid: 18.4 g; mp 127°-219° C. ##STR30##

Fuente