Reacción #96007

Ecuación de reacción

4-methylthiosemicarbazide

acetone

2-fluorobenzoyl chloride

→

desired product

4-(2-Fluorobenzoyl)-2-methylamino-5,5-dimethyl-4,5-dihydro-1,3,4-thiadiazole

Disolventes

pyridine

Condiciones de reacción

Procedimiento

A 42 g. portion of 4-methylthiosemicarbazide was reacted with 400 ml. of acetone, and then with 32 ml. of pyridine and 63.6 g. of 2-fluorobenzoyl chloride to prepare 66.5 g. of the desired product, m.p. 136°-140°.

Fuente