Reacción #9573

Ecuación de reacción

9-Bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline

4-propoxyphenylboronic acid

→

1-(2-methylpropyl)-9-(4-propoxyphenyl)-1H-imidazo[4,5-c]quinoline

Rendimiento 90.0%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe crude product was purified by HPFC (
2. 2
   Lavadoeluting with chloroform

Procedimiento

9-Bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline (1.0 g, 3.4 mmol) and 4-propoxyphenylboronic acid (1.0 g, 5.5 mmol) were coupled according to Part J of Example 1. The palladium (II) acetate (2.5 mg, 0.011 mmol) was added as a 5 mg/mL solution in toluene. The work-up procedure described in Parts 125–135 was followed. The crude product was purified by HPFC (eluting with chloroform:CMA in a gradient from 100:0 to 70:30) to provide 1.1 g of 1-(2-methylpropyl)-9-(4-propoxyphenyl)-1H-imidazo[4,5-c]quinoline as a dark brown oil.

Fuente