Reacción #95724

Ecuación de reacción

8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxaldehyde-3-oxime

→

8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carbonitrile

Disolventes

acetic acid anhydride

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe mixture is evaporated
2. 2
   Lavadothe solution is washed once with saturated sodium hydrogen carbonate solution and once with water
3. 3
   SecadoThe chloroform solution is dried over magnesium sulphate
4. 4
   Concentraciónconcentrated
5. 5
   OtroAfter column chromatography and recrystallisation from ethyl acetate

Procedimiento

1.65 g (6 mmol) of 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxaldehyde-3-oxime are heated to boiling under reflux for 4.5 hours in 15 ml of acetic acid anhydride and the mixture is evaporated. The residue is taken up in 100 ml of chloroform and the solution is washed once with saturated sodium hydrogen carbonate solution and once with water. The chloroform solution is dried over magnesium sulphate and concentrated. After column chromatography and recrystallisation from ethyl acetate, there is obtained 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carbonitrile of melting point 236°-237° C.

Fuente