Reacción #9572

Ecuación de reacción

9-Bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline

benzene boronic acid

→

1-(2-methylpropyl)-9-phenyl-1H-imidazo[4,5-c]quinoline

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe crude product was purified by HPFC (
2. 2
   Lavadoeluting with chloroform

Procedimiento

9-Bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline (0.34 mmol) and benzene boronic acid (62 mg, 0.51 mmol) were coupled according to Part J of Example 1. The work-up procedure described in Parts 125–135 was followed. The crude product was purified by HPFC (eluting with chloroform:CMA in a gradient from 100:0 to 85:15) to provide 1-(2-methylpropyl)-9-phenyl-1H-imidazo[4,5-c]quinoline.

Fuente