Reacción #956412

Ecuación de reacción

sodium hydrogen carbonate

sodium sulfite

1-(isopropylsulfanyl)-4-methyl-2-nitrobenzene

m-chloroperbenzoic acid

→

2-(isopropylsulfonyl)-4-methyl-1-nitrobenzene

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   OtroAfter the reaction liquid
3. 3
   Temperaturawas cooled
4. 4
   Otrothe reaction liquid
5. 5
   Extracciónwas extracted with chloroform
6. 6
   SecadoAfter the organic layer was dried over anhydrous sodium sulfate
7. 7
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

Procedimiento

To a mixture of 1-(isopropylsulfanyl)-4-methyl-2-nitrobenzene (Preparation Example 287) (6.60 g) and chloroform (150 mL), m-chloroperbenzoic acid (18.0 g) was added and stirred at 50° C. for 12 hours. After the reaction liquid was cooled, saturated aqueous sodium hydrogen carbonate and 5% aqueous sodium sulfite were added, and the reaction liquid was extracted with chloroform. After the organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to give 2-(isopropylsulfonyl)-4-methyl-1-nitrobenzene (7.41 g) as a yellow solid.

Fuente