Reacción #956411

Ecuación de reacción

propane-2-thiol

potassium carbonate

DMF

1-fluoro-4-methyl-2-nitrobenzene

→

1-(isopropylsulfanyl)-4-methyl-2-nitrobenzene

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   Otrothe reaction liquid
3. 3
   Extracciónwas extracted with ethyl acetate
4. 4
   Lavadothe extract was washed with water and saturated aqueous sodium chloride
5. 5
   SecadoAfter drying over anhydrous sodium sulfate
6. 6
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

Procedimiento

To a mixture of propane-2-thiol (3.30 mL), potassium carbonate (6.60 g) and DMF (40 mL), 1-fluoro-4-methyl-2-nitrobenzene (4.85 g) was added and stirred at room temperature for 5 hours. After addition of water, the reaction liquid was extracted with ethyl acetate, and the extract was washed with water and saturated aqueous sodium chloride. After drying over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to give 1-(isopropylsulfanyl)-4-methyl-2-nitrobenzene (6.60 g) as a yellow oil.

Fuente