Reacción #95527

Ecuación de reacción

hydrochloric acid

2-hydroxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate

benzoyl chloride

→

2-benzoyloxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrodid not exceed 10° C
2. 2
   ExtracciónThe product was extracted with ether
3. 3
   Lavadothe ethereal solution washed
4. 4
   Secadodried with sodium sulphate
5. 5
   Otroevaporated
6. 6
   Otroto give an oil which
7. 7
   OtroThe solid was recrystallised from a mixture of benzene and light petroleum

Procedimiento

To a cooled solution of 2-hydroxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate (8.0 parts) in dry pyridine (42 parts) was added benzoyl chloride (4.75 parts) at such a rate that the temperature did not exceed 10° C. After one hour the mixture was poured into a slight excess of dilute hydrochloric acid. The product was extracted with ether and the ethereal solution washed, dried with sodium sulphate and evaporated to give an oil which solidified on scratching. The solid was recrystallised from a mixture of benzene and light petroleum to give 2-benzoyloxy-2,3-dihydro-3,3-dimethylbenzofuran-5-yl methanesulphonate (5.1 parts), melting point 102°-104° C.

Fuente