Reacción #95490

ord-e35e51a9007543e7abef36f47aab62cf

Ecuación de reacción

N#CN1CCC2(CC1)CN(c1ccccc1)c1ccccc12
1'-cyano-1-phenylspiro[indoline-3,4'-piperidine]
Cl
hydrochloric acid
→
c1ccc(N2CC3(CCNCC3)c3ccccc32)cc1
1-phenylspiro[indoline-3,4'-piperidine]

Reactantes

N#CN1CCC2(CC1)CN(c1ccccc1)c1ccccc12
1'-cyano-1-phenylspiro[indoline-3,4'-piperidine]
Cl
hydrochloric acid

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Temperaturaunder reflux

Procedimiento

A mixture of 1'-cyano-1-phenylspiro[indoline-3,4'-piperidine] (Example 8), is treated with 3 N hydrochloric acid under reflux to provide 1-phenylspiro[indoline-3,4'-piperidine].

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04345081uspto-grants-1982_08