Reacción #95387

Ecuación de reacción

acetyl chloride

acetic anhydride

1-(2-hydroxyethyl)pyrrole

1-(2-hydroxyethyl)pyrrole

sulfuric acid

pyrrole

acetyl chloride

acetic anhydride

→

1-(2-acetoxyethyl)pyrrole

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheating the reaction mixture sufficiently
2. 2
   workup.DISTILLATIONto distill off the water that
3. 3
   Otrois formed as
4. 4
   Otroa result of the reaction
5. 5
   Otroat room temperature
6. 6
   workup.WAITwill be completed in a relatively short period of time, with only an hour
7. 7
   Otrotwo at the most being required for the reaction

Procedimiento

Once the 1-(2-hydroxyethyl)pyrrole is obtained, it is esterified by any suitable means known in the art. Suitably, acetic acid is reacted with the 1-(2-hydroxyethyl)pyrrole in the presence of a strong acid such as sulfuric acid and heating the reaction mixture sufficiently to distill off the water that is formed as a result of the reaction. Preferably however, the pyrrole is reacted with acetyl chloride or acetic anhydride in a suitable solvent wherein there is a molar excess of the acetyl chloride or acetic anhydride. The reaction takes place at room temperature and will be completed in a relatively short period of time, with only an hour or two at the most being required for the reaction to reach completion. The 1-(2-acetoxyethyl)pyrrole is then isolated and purified by any means known in the art such as extraction with a suitable organic solvent and removal of the solvent to yield the desired compound represented by Formula (III).

Fuente