Reacción #95358

Ecuación de reacción

1-(4-chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

sodium borohydride

→

desired product

Rendimiento 58.6%

1-[2-(4-Chlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

Rendimiento 58.6%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe white crystals deposited are separated by filtration
2. 2
   Lavadosuccessively washed with methanol and water
3. 3
   Otrodried
4. 4
   Otroto obtain 2.07 g of a crude product
5. 5
   OtroThe crude product is recrystallized from a mixed solvent of chloroform and ethanol

Procedimiento

In this example, 2.70 g of 1-(4-chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine and 150 ml of methanol are mixed and stirred at room temperature. To the stirred mixture, 2.0 g of sodium borohydride is added over a period of 5 hours. Then, the resultant mixture is stirred overnight at room temperature. The white crystals deposited are separated by filtration, successively washed with methanol and water and dried to obtain 2.07 g of a crude product. The crude product is recrystallized from a mixed solvent of chloroform and ethanol to obtain 1.59 g of the desired product.

Fuente