Reacción #95357

Ecuación de reacción

1-(3-chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

sodium borohydride

→

desired product

Rendimiento 57.7%

1-[2-(3-Chlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

Rendimiento 57.7%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThen, the mixture is stirred overnight at room temperature
2. 2
   OtroThe white crystals deposited are separated by filtration
3. 3
   Lavadosuccessively washed with methanol and water
4. 4
   Otrodried
5. 5
   Otroto obtain 1.21 g of a crude product
6. 6
   OtroThe crude product is recrystallized from a mixed solvent of chloroform and ethanol

Procedimiento

In this example, 1.50 g of 1-(3-chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine and 75 ml of methanol are mixed and stirred at room temperature. To the stirred mixture, 1.0 g of sodium borohydride is added over a period of 5 hours. Then, the mixture is stirred overnight at room temperature. The white crystals deposited are separated by filtration, successively washed with methanol and water and dried to obtain 1.21 g of a crude product. The crude product is recrystallized from a mixed solvent of chloroform and ethanol to obtain 0.87 g of the desired product.

Fuente