Reacción #95353

Ecuación de reacción

4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine mono-hydrochloride

α-bromo-m-chloroacetophenone

triethylamine

→

desired product

Rendimiento 50.4%

1-(3-Chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidin

Rendimiento 50.4%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThen, the white crystals deposited are separated by filtration
2. 2
   Lavadosuccessively washed with methanol and water
3. 3
   Otrodried
4. 4
   Otroto obtain 2.89 g of a crude product
5. 5
   OtroThe crude product is recrystallized from a mixed solvent of chloroform and ethanol

Procedimiento

In this example, 2.67 g of 4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine mono-hydrochloride, 2.33 g of α-bromo-m-chloroacetophenone, 2.8 ml of triethylamine and 30 ml of methanol are mixed and stirred at room temperature overnight. Then, the white crystals deposited are separated by filtration, successively washed with methanol and water and dried to obtain 2.89 g of a crude product. The crude product is recrystallized from a mixed solvent of chloroform and ethanol to obtain 1.93 g of the desired product.

Fuente