Reacción #95326

Ecuación de reacción

disodium

(24R)-22ξ-phenylsulfonyl-5,7-cholestadiene-3β,24,25-triol 3-tetrahydropyranyl ether

→

(24R)-5,7-cholestadiene-3β,24,25-triol 3-tetrahydropyranyl ether

Rendimiento 93.0%

Disolventes

methanol

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture was stirred for 30 minutes at room temperature
2. 2
   Filtraciónthe precipitate was filtered
3. 3
   OtroThe filtrate was evaporated under reduced pressure
4. 4
   Extracciónthe residue was extracted with ethyl acetate
5. 5
   LavadoThe organic layer was washed with saturated brine
6. 6
   Secadodried over anhydous sodium sulfate
7. 7
   OtroThe solvent was evaporated under reduced pressure

Procedimiento

A mixture of 1 g of anhydrous disodium hydrogenephosphate and 3.2 g of 5% sodium-amalgam was added to a solution of 160 mg of (24R)-22ξ-phenylsulfonyl-5,7-cholestadiene-3β,24,25-triol 3-tetrahydropyranyl ether in 5 ml of methanol in an argon stream under stirring, and the mixture was stirred for 30 minutes at room temperature. To the reaction mixture 10 ml of methanol was added and the precipitate was filtered. The filtrate was evaporated under reduced pressure and the residue was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydous sodium sulfate. The solvent was evaporated under reduced pressure to give 11.6 mg (93%) of (24R)-5,7-cholestadiene-3β,24,25-triol 3-tetrahydropyranyl ether.

Fuente