Reacción #95223

Ecuación de reacción

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2,4-dichlorobenzoyl chloride

→

pure product

Rendimiento 69.5%

5-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Rendimiento 69.5%

Disolventes

xylene

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated in vacuo
2. 2
   Extracciónthe resulting residue extracted with benzene
3. 3
   workup.ADDITIONAddition of hexane

Procedimiento

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.9 g (0.10 mole) 2,4-dichlorobenzoyl chloride was refluxed in 200 ml xylene for 20 hours. The reaction mixture was concentrated in vacuo and the resulting residue extracted with benzene. Addition of hexane resulted in precipitation of 13.6 g (69% yield) pure product; m.p. 136° C.

Fuente