Reacción #95219

Ecuación de reacción

5-amino-3-trichloromethyl-1,2,4-thiadiazole

3,5-dinitrobenzoyl chloride

→

pure product

Rendimiento 85.0%

5-(3,5-Dinitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Rendimiento 85.0%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe crude product precipitated from the reaction mixture
2. 2
   FiltraciónAfter isolation by filtration
3. 3
   Lavadothe residue was washed with hot petroleum ether
4. 4
   Otrofinally recrystallized from methylene chloride

Procedimiento

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 12.6 g (0.055 mole) 3,5-dinitrobenzoyl chloride in 200 ml toluene was refluxed for 20 hours. The crude product precipitated from the reaction mixture upon cooling to -10° C. After isolation by filtration, the residue was washed with hot petroleum ether and finally recrystallized from methylene chloride to give 17.5 g (85% yield) of pure product; m.p. 197° C.

Fuente