Reacción #95217

Ecuación de reacción

5-amino-3-trichloromethyl-1,2,4-thiadiazole

3-nitrobenzoyl chloride

→

pure product

Rendimiento 69.1%

5-(3-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Rendimiento 69.1%

Disolventes

xylene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 20 hours
2. 2
   OtroUnreacted starting amino compound was recovered
3. 3
   Temperaturaby cooling the reaction mixture
4. 4
   Filtraciónfiltering the resulting precipitate
5. 5
   ConcentraciónThe filtrate was concentrated in vacuo
6. 6
   Otrothe residue recrystallized from xylene
7. 7
   LavadoAfter washing with petroleum ether

Procedimiento

A solution of 21.8 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 18.6 g (0.1 mole) 3-nitrobenzoyl chloride in 250 ml xylene was heated at reflux for 20 hours. Unreacted starting amino compound was recovered by cooling the reaction mixture and filtering the resulting precipitate. The filtrate was concentrated in vacuo and the residue recrystallized from xylene. After washing with petroleum ether, 25.4 g (69% yield) of pure product was obtained; m.p. 198° C.

Fuente