Reacción #95215

Ecuación de reacción

5-amino-3-trichloromethyl-1,2,4-thiadiazole

4-toluoyl chloride

→

crude product

5-(4-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 20 hours
2. 2
   OtroUnreacted amino compound was removed
3. 3
   Temperaturaby cooling the reaction mixture
4. 4
   Filtraciónfiltering the precipitate

Procedimiento

A solution of 11.0 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 8.0 g (0.05 mole) 4-toluoyl chloride in 250 ml toluene was heated at reflux for 20 hours. Unreacted amino compound was removed by cooling the reaction mixture and filtering the precipitate. Concentration of the filtrate in vacuo gave the crude product, which was purified by recrystallization from cyclohexane. Yield was 9.1 g (27%); m.p. 127° C.

Fuente