Reacción #95103

Ecuación de reacción

5-bromo-valeric acid ethylester

5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester

sodium hydride

→

5-(2-Ethoxycarbonyl-5-benzyloxy-3-phenyl-1H-indole-1-yl)-valeric acid-ethylester

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter evaporation
2. 2
   Otrothe residue obtained
3. 3
   Otrowas chromatographed on silicagel (solvent: toluene/acetone (20.1))

Procedimiento

An amount of 23.5 g (63.3 m mole) of 5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester in absolute dimethylformamide was mixed with 3.0 g (63.3 m mole) of 50% sodium hydride. After 30 minutes, 13.2 g (63.3 m mole) of 5-bromo-valeric acid ethylester were added, and the mixture was stirred for three days. After evaporation, the residue obtained was chromatographed on silicagel (solvent: toluene/acetone (20.1)).

Fuente