Reacción #95016

Ecuación de reacción

2-amino-5-methylpyrazine

bromine

sodium hydroxide

sodium acetate trihydrate

→

2-Amino-3-bromo-5-methylpyrazine

Disolventes

acetic acid

acetic acid

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat 2° C.
2. 2
   workup.ADDITIONpoured into ice
3. 3
   Filtraciónfiltered
4. 4
   Extracciónresidue extracted with ether
5. 5
   Otrothe 2-amino-3-bromo-5-methylpyrazine crystallized from a suitable solvent

Procedimiento

To acetic acid (1500 ml.), 2-amino-5-methylpyrazine (1 mole) and 326.5 g. sodium acetate trihydrate are slowly added 1.1 mole bromine in 180 ml. acetic acid at 2° C. in the absence of light. The mixture is stirred about 15 hours at 20° C., stripped of acetic acid in vacuo, poured into ice, made alkaline with sodium hydroxide, filtered, and residue extracted with ether, the extract stripped and the 2-amino-3-bromo-5-methylpyrazine crystallized from a suitable solvent.

Fuente