Reacción #9491

ord-430d0386e8414621b64afa9b24284926

Ecuación de reacción

O=[N+]([O-])c1cnc2cc(Br)ccc2c1Cl
7-Bromo-4-chloro-3-nitroquinoline
NCCCN1CCCC1=O
1-(3-aminopropyl)pyrrolidin-2-one
→
O=C1CCCN1CCCNc1c([N+](=O)[O-])cnc2cc(Br)ccc12
1-[3-(7-bromo-3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one
Rendimiento 84.0%

Reactantes

O=[N+]([O-])c1cnc2cc(Br)ccc2c1Cl
7-Bromo-4-chloro-3-nitroquinoline
NCCCN1CCCC1=O
1-(3-aminopropyl)pyrrolidin-2-one

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

7-Bromo-4-chloro-3-nitroquinoline (35.26 g, 123.8 mmol) was treated with 1-(3-aminopropyl)pyrrolidin-2-one (19.1 mL, 136.2 mmol) according to the method described in Part E of Example 1 to provide 40.87 g of 1-[3-(7-bromo-3-nitroquinolin-4-ylamino)propyl]pyrrolidin-2-one as a yellow solid.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07091214B2uspto-grants-2006_08