Reacción #94840

Ecuación de reacción

phenyl isothiocyanate

triethylamine

1,3-dimethyl-2-imino-imidazolidine hydrobromide

→

N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea

Disolventes

chloroform

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture is refluxed for 15 hours
2. 2
   TemperaturaAfter cooling
3. 3
   Lavadoit is washed with water
4. 4
   Secadodried over sodium sulfate
5. 5
   Otroevaporated in vacuo

Procedimiento

30.4 g (0.3 mol) of triethylamine are added to a suspension of 58.2 g (0.3 mol) of 1,3-dimethyl-2-imino-imidazolidine hydrobromide in 470 ml of chloroform, at 5°, with stirring. A solution of 40.6 g (0.3 mol) of phenyl isothiocyanate in 235 ml of chloroform is then added dropwise and the reaction mixture is refluxed for 15 hours. After cooling, it is washed with water, dried over sodium sulfate and evaporated in vacuo. Crude N-(1,3-dimethyl-2-imidazolidinylidene)-N'-phenyl-thiourea is obtained and after recrystallisation from ethanol this melts at 195°-196°.

Fuente