Reacción #94767

Ecuación de reacción

hydrochloric acid

1-methyl-2-pyrrolecarboxaldehyde

α-(1-methyl-2-pyrrolyl)-4-morpholineacetonitrile

ethyl acrylate

→

3-(1-methyl-2-pyrrolylcarbonyl)propionic acid

Condiciones de reacción

Procedimiento

As for Example 6, 1-methyl-2-pyrrolecarboxaldehyde is converted to α-(1-methyl-2-pyrrolyl)-4-morpholineacetonitrile. The preceding compound is reacted with ethyl acrylate and the resulting 1,4-addition product is heated at 100° C. with 6 N hydrochloric acid to give 3-(1-methyl-2-pyrrolylcarbonyl)propionic acid.

Fuente