Reacción #94722

Ecuación de reacción

2-amino-4,5,6-trimethylpyrimidine

methylene chloride

methyl 2-(isocyanatosulfonyl)benzoate

→

Methyl 2-{[(4,5,6-trimethylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl}benzoate

Disolventes

Butyl chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGwith constant stirring
2. 2
   Filtraciónthe insoluble product filtered
3. 3
   Lavadowashed immediately with butyl chloride
4. 4
   Otrodried

Procedimiento

To a mixture of 1.0 gram (0.0073 mole) of 2-amino-4,5,6-trimethylpyrimidine and 5.0 ml of dried methylene chloride stirring magnetically in a 50 ml RB single neck flask, 2.1 grams of methyl 2-(isocyanatosulfonyl)benzoate was added at room temperature and the mixture stirred at room temperature for 24 hours. Butyl chloride (4 ml) was added with constant stirring and the insoluble product filtered, washed immediately with butyl chloride and dried. (Yield 1.3 grams, m.p. 152°-161°). IR (Nujol): 5.60, 5.75 (C=O), 11.25 11.90 microns; NMR (TFA-d): δ2.30 (s,3H,CH3), 2.65 (s, 6H, 2CH3), 4.00 (s, 3H, CO2CH3), 7.60-8.60 (m, ArH).

Fuente