Reacción #94691

Ecuación de reacción

ethyl mercaptoacetate

4-chloro-1-(2-furyl)-1-butanol

sodium ethoxide

→

4-(carbethoxymethylthio)-1-(2-furyl)-1-butanol

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaTo a stirred, refluxing
2. 2
   Temperaturaat reflux for 3 hours
3. 3
   Temperaturacooled
4. 4
   Concentraciónconcentrated
5. 5
   Otroto remove most of the ethanol
6. 6
   OtroThe residue is partitioned with ether and water
7. 7
   LavadoThe ether phase is washed with brine
8. 8
   Secadodried over potassium carbonate
9. 9
   ConcentraciónThe solution is concentrated
10. 10
    workup.ADDITIONdiluted with xylene
11. 11
    Otroto give an oil

Procedimiento

To a stirred, refluxing mixture of ethyl mercaptoacetate, and 4-chloro-1-(2-furyl)-1-butanol (Example 160), and sodium ethoxide in ethanol. The resulting mixture is stirred at reflux for 3 hours, cooled, and concentrated to remove most of the ethanol. The residue is partitioned with ether and water. The ether phase is washed with brine and dried over potassium carbonate. The solution is concentrated, diluted with xylene, and again conentrated to give an oil.

Fuente