Reacción #9454

Ecuación de reacción

7-Bromo-2-ethoxymethyl-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

thiophene-3-boronic acid

→

2-ethoxymethyl-1-isobutyl-7-(thiophen-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroRecrystallization from isopropanol
2. 2
   Otrofollowed by purification on silica gel (5% methanol in CH2Cl2 to 7% methanol in CH2Cl2 gradient)

Procedimiento

7-Bromo-2-ethoxymethyl-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and thiophene-3-boronic acid were coupled according to the general procedure described in Part J of Example 1. Recrystallization from isopropanol followed by purification on silica gel (5% methanol in CH2Cl2 to 7% methanol in CH2Cl2 gradient) afforded 2-ethoxymethyl-1-isobutyl-7-(thiophen-3-yl)-1H-imidazo[4,5-c]quinolin-4-amine as a pale yellow solid, m.p. 187–189° C.

Fuente