Reacción #945

Ecuación de reacción

benzaldehyde

product

Ethyl 2-aminobutyrate hydrochloride

magnesium sulphate

triethylamine

→

desired product

Rendimiento 88.9%

Ethyl 2-benzylideneaminobutyrate

Rendimiento 88.9%

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthen filtered
2. 2
   ConcentraciónThe filtrate was concentrated
3. 3
   Otrotriturated in diethyl ether
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated

Procedimiento

A solution of the product from step (a) (149.6 g), magnesium sulphate (74.3 g), and triethylamine (246 ml) in dichloromethane (1500 ml) was stirred at room temperature under nitrogen and benzaldehyde (94.9 g, Aldrich) was added dropwise. The mixture was stirred at room temperature for 3 hours then filtered. The filtrate was concentrated, triturated in diethyl ether, filtered and concentrated to yield the desired product as a yellow oil (174 g). 1H NMR consistent with the proposed structure.

Fuente