Reacción #94330

Ecuación de reacción

sodium hydroxide

ampicillin trihydrate

→

sodium ampicillin

Rendimiento 98.7%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawhile cooling
2. 2
   FiltraciónThe resulting clear solution was immediately sterile-filtered
3. 3
   Filtraciónfiltered
4. 4
   Otroto remove
5. 5
   Temperaturafrozen in bulk by the shell-freezing process

Procedimiento

6 ml of an aqueous 1N sodium hydroxide solution (6 millimols of NaOH) which had been cooled to about 0° C. was added dropwise over a period of 5 minutes to a suspension of 2.42 gm (6 millimols) of ampicillin trihydrate in 24 ml of water at about 0° C., while cooling and vigorously stirring. The resulting clear solution was immediately sterile-filtered, that is, filtered to remove suspended particles, and the filtrate was without delay frozen in bulk by the shell-freezing process. Thereafter, the frozen filtrate was lyophilized, yielding 2.2 gm of white sodium ampicillin having a residual moisture content of 1.35% by weight and a microbiological activity of 94% (U.S.P. standard).

Fuente