Reacción #942680

ord-fdaef98d1ae04ed49cdf1b22e883e169

Ecuación de reacción

CN
methylamine
Nc1nc(I)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
2-iodoadenosine
→
CNC1(N)N=C(I)N=C2C1=NCN2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
2-iodo-6-methylamino adenosine

Reactantes

CN
methylamine
Nc1nc(I)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
2-iodoadenosine

Reactivos

Ninguno

Disolventes

CO
methanol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    FiltraciónThe precipitate was filtered off
  2. 2
    Lavadowashed with ether
  3. 3
    Otrodried under vacuum

Procedimiento

A mixture of 40% aqueous methylamine (1 mL) and 2-iodoadenosine (100 mg) in methanol (2 mL) was stirred at room temperature for 12 hours. The precipitate was filtered off, washed with ether and dried under vacuum to afford 2-iodo-6-methylamino adenosine, a compound of formula (11).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07262176B2uspto-grants-2007_08