Reacción #94247

Ecuación de reacción

4-hydroxy-4-phenylpiperidine

ethyl trifluoroacetate

→

1-trifluoroacetyl-4-hydroxy-4-phenylpiperidine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe starting material is prepared
2. 2
   Temperaturais refluxed overnight
3. 3
   Otroevaporated
4. 4
   Lavadothe solution washed with 1N hydrochloric acid
5. 5
   Otrodried
6. 6
   Otroevaporated
7. 7
   OtroThe residue is recrystallized from ethyl acetate-petroleum ether

Procedimiento

The starting material is prepared as follows: The mixture of 25 g of 4-hydroxy-4-phenylpiperidine and 50 ml of ethyl trifluoroacetate is refluxed overnight and evaporated. The residue is taken up in benzene, the solution washed with 1N hydrochloric acid, dried and evaporated. The residue is recrystallized from ethyl acetate-petroleum ether, to yield the 1-trifluoroacetyl-4-hydroxy-4-phenylpiperidine melting at 123°-125°.

Fuente