Reacción #9422

Ecuación de reacción

iodoethane

oxindole

n-butyl lithium

NH4Cl

N,N,N′,N′-tetramethylethylenediamine

→

3-ethyl-indol-2-one

Rendimiento 2.9%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with EtOAc (2×)
2. 2
   Lavadothe combined organic layers were washed with dil. HCl, water, brine
3. 3
   Secadodried (MgSO4)
4. 4
   Concentraciónconcentrated
5. 5
   OtroThe residual oil was triturated with hexane
6. 6
   Otroto afford the crude product (24.5 g, 51%)
7. 7
   OtroA sample (3 g) was recrystallized from EtOAc/hexane

Procedimiento

A solution of oxindole (40 g, 0.3 mol) in dry THF (400 ml) under N2 was cooled to −25° C. and treated drop wise with n-butyl lithium (2.5M in hexanes, 240 ml, 0.6 mol). To the resulting solution was added N,N,N′,N′-tetramethylethylenediamine (90.4 ml, 0.6 mol). After 30 min. iodoethane (48 ml, 0.6 mol) was added and the reaction mixture was allowed to warm to room temperature and stirred over night. The reaction mixture was poured into aqueous NH4Cl solution, extracted with EtOAc (2×) and the combined organic layers were washed with dil. HCl, water, brine, dried (MgSO4) and concentrated. The residual oil was triturated with hexane to afford the crude product (24.5 g, 51%). A sample (3 g) was recrystallized from EtOAc/hexane to obtain 3-ethyl-indol-2-one (1.4 g), m.p. 100–101° C.; 1H-NMR (DMSO-d6) δ 0.76 (t, 3H, J=7.5 Hz), 1.8–2.0 (m, 2H), 3.38 (t, 3H, J=5.7 Hz), 6.8 (dt, 1H, J=7.69, 0.45 Hz), 6.93 (dt, 1H, J=7.45, 1.10 Hz), 7.15 (m, 1H), 7.22 (m, 1H), 10.3 (s, 1H); MS (ESI) m/z 270 [M+H].

Fuente