Reacción #93855

Ecuación de reacción

2,2-dimethyl-1-ethinyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-naphthol

→

2,2-Dimethyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-vinyl-1-naphthol

Rendimiento 95.0%

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrois submitted to hydrogenation at atmospheric pressure and room temperature
2. 2
   OtroAfter the absorption of 1200 ml of hydrogen the catalysts
3. 3
   Otroare removed by filtration
4. 4
   ConcentraciónThe solution is concentrated by evaporation in vacuo of most of the solvent
5. 5
   Otrowhereafter the product crystallizes as white crystals melting at 152°-154° C

Procedimiento

A mixture of 205 g of 2,2-dimethyl-1-ethinyl-7-methoxy-3-(N-methyl-p-toluenesulphonamido)-1,2,3,4-tetrahydro-1-naphthol, 0.8 g of 0,5% palladium on calcium carbonate, 0.8 g 5% palladium on charcoal and 1000 ml of ethyl acetate is submitted to hydrogenation at atmospheric pressure and room temperature. After the absorption of 1200 ml of hydrogen the catalysts are removed by filtration. The solution is concentrated by evaporation in vacuo of most of the solvent, whereafter the product crystallizes as white crystals melting at 152°-154° C. Yield 95%.

Fuente