Reacción #93728

Ecuación de reacción

tetrafluoroisophthalonitrile

acetonitrile

sodium bicarbonate

→

desired compound

Rendimiento 61.0%

4-Amino-2,5,6-trifluoroisophthalonitrile

Rendimiento 61.0%

Disolventes

ammonia

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONAfter the dropwise addition
2. 2
   Extracciónthe resultant mixture was extracted with chloroform
3. 3
   Lavadowas washed with an aqueous sodium chloride solution
4. 4
   SecadoAfter drying with sodium sulfate
5. 5
   workup.DISTILLATIONthe chloroform was distilled off
6. 6
   Otroto obtain yellow crystal
7. 7
   OtroThe resultant crystal was recrystallized from chloroform

Procedimiento

To a solution of 2.0 g of tetrafluoroisophthalonitrile in 20 ml of acetonitrile, 0.6 ml of 28% aqueous ammonia was dropwise added. After the dropwise addition, the mixture was stirred at room temperature for one hour. An aqueous sodium bicarbonate solution was added to the mixture and the resultant mixture was extracted with chloroform and was washed with an aqueous sodium chloride solution. After drying with sodium sulfate, the chloroform was distilled off to obtain yellow crystal. The resultant crystal was recrystallized from chloroform to obtain 1.2 g (61% yield) of the desired compound No. 1.

Fuente