Reacción #93722

Ecuación de reacción

chloropurine riboside

triethyl amine

N-[(1,2-dihydro-1-acenaphthylenyl)methyl]amine

→

white solid

Rendimiento 85.0%

N6 -[(1,2-Dihydro-1-acenaphthylenyl)methyl]adenosine

Rendimiento 85.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered free of solid
2. 2
   LavadoThe solution was washed with ethanol (50 ml)
3. 3
   Otrodried at 65° C. in vacuo for four hours

Procedimiento

Six chloropurine riboside (1.7 g, 6 mmol), triethyl amine (1.5 g, 15 mmol) and the N-[(1,2-dihydro-1-acenaphthylenyl)methyl]amine, B, as prepared in the following Example B (1.4 g, 6.4 mmol) were stirred at reflux in ethanol (100 ml) overnight. The solution was cooled to room temperature and filtered free of solid. The solution was washed with ethanol (50 ml) and dried at 65° C. in vacuo for four hours, to give 2.2 g (85%) of a white solid, mp 173°-175° C. Anal. (C23H23N5O4); calc: C=63.73, H=5.35, N=16.16; found: C=63.55, H=5.49, N=16.00.

Fuente