Reacción #93538

Ecuación de reacción

pyridine

α-mercaptomethyl-β-phenyl-γ-butyrolactone

p-n-butylbenzoyl chloride

→

title compound

Rendimiento 79.1%

α-(p-n-butylbenzoylthiomethyl)-β-phenyl-γ-butyrolactone

Rendimiento 79.1%

Disolventes

ethyl ether

ethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter completion of the reaction
2. 2
   Lavadowashed with 10% hydrochloric acid, 10% aqueous sodium hydrogen carbonate
3. 3
   Secadodried over magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   OtroThe crude product thus obtained
6. 6
   Otrowas purified by a silica gel column chromatography

Procedimiento

To a solution of 1.5 g of α-mercaptomethyl-β-phenyl-γ-butyrolactone in 30 ml of ethyl ether were added at room temperature 4.3 g of p-n-butylbenzoyl chloride and then 1.9 ml of pyridine. The mixture was kept at room temperature for 2.5 hours. After completion of the reaction, the reaction mixture was diluted with 100 ml of ethyl ether, washed with 10% hydrochloric acid, 10% aqueous sodium hydrogen carbonate and then satureated saline, dried over magnesium sulfate and the solvent was distilled off. The crude product thus obtained was purified by a silica gel column chromatography to give 2.1 g (yield 79%) of the title compound.

Fuente