Reacción #9351

Ecuación de reacción

4-benzyloxyphenol

allylbromide

K2CO3

acetone

→

desired product

2,6-diallyl-4-benzyloxyphenol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was refluxed overnight
2. 2
   Otrothe insoluble materials were removed by filtration
3. 3
   ConcentraciónThe filtrate was concentrated in vac
4. 4
   OtroThe residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL)
5. 5
   LavadoThe organic layer was washed with water and brine
6. 6
   Secadodried over anhydrous MgSO4
7. 7
   Filtraciónfiltered
8. 8
   Concentraciónconcentrated in vac

Procedimiento

To a solution of starting 4-benzyloxyphenol (20 g) in acetone (800 mL) were added allylbromide (50 mL) and K2CO3 (60 g). The reaction mixture was refluxed overnight. After cooling to the room temperature, the insoluble materials were removed by filtration. The filtrate was concentrated in vac. The residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL). The organic layer was washed with water and brine, dried over anhydrous MgSO4, filtered, and concentrated in vac. to give the desired product.

Fuente