Reacción #93498

Ecuación de reacción

1-(2-phenyl-4-quinolyl)-2-(4-piperidyl)-ethanol

methyl iodide

potassium carbonate

water

→

2-(1-methyl-4-piperidyl)-1-(2-phenyl-4-quinolyl)-ethanol

Rendimiento 37.9%

Disolventes

dimethylformamide

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic phase was separated
2. 2
   Secadodried over magnesium sulfate
3. 3
   Otroevaporated under reduced pressure
4. 4
   Otro1 g of crude product was obtained which
5. 5
   LavadoThe elution

Procedimiento

A mixture of 2.55 g of 1-(2-phenyl-4-quinolyl)-2-(4-piperidyl)-ethanol (racemic), 1.1 g of methyl iodide and 0.6 g of potassium carbonate in 20 ml of dimethylformamide was stirred for 2 hours at the ambient temperature. 20 ml of water and 30 ml of toluene were then added. The organic phase was separated, wahsed with water, dried over magnesium sulfate and evaporated under reduced pressure. 1 g of crude product was obtained which was fixed on a column of silica gel. The elution was effected with a 9/1 chloroform-diethylamine mixture. 0.57 g of 2-(1-methyl-4-piperidyl)-1-(2-phenyl-4-quinolyl)-ethanol (racemic), which melted at 208° C. was thus isolated.

Fuente