Reacción #93488

Ecuación de reacción

5-(4-chlorobutyryl)-2-benzyloxy-benzamide

1-phenylpiperazine

triethylamine

dimethyl sulfoxide

→

5-[4-(4-phenyl-1-piperazinyl)butyryl]-2-benzyloxy-salicylamide

Rendimiento 58.0%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture was extracted with ethyl acetate
2. 2
   LavadoThe extract was washed with water saturated with sodium chloride
3. 3
   Secadodried over anhydrous sodium sulfate
4. 4
   Concentraciónconcentrated
5. 5
   OtroThe thus-produced residue was crystallized from ethyl acetate-ether

Procedimiento

A mixture of 1 g of 5-(4-chlorobutyryl)-2-benzyloxy-benzamide, 1.2 g of 1-phenylpiperazine, 3.3 ml of triethylamine and 10 ml of dimethyl sulfoxide was heated at 90° C. for 15 hours while stirring. After the reaction was finished, water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The extract was washed with water saturated with sodium chloride, dried over anhydrous sodium sulfate and concentrated. The thus-produced residue was crystallized from ethyl acetate-ether to obtain 1.6 g of 5-[4-(4-phenyl-1-piperazinyl)butyryl]-2-benzyloxy-salicylamide (yield: 58.0%).

Fuente