Reacción #93468

Ecuación de reacción

2-chloropyrimidine

1-(6-benzodioxinyl methyl)piperazine

potassium carbonate

→

1-(benzodioxin-6-yl methyl)-4-(pyrimidin-2-yl)piperazine dihydrochloride

Rendimiento 156.5%

Disolventes

pentanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter the completion of the reaction
2. 2
   Filtraciónthe so-formed salt was filtered off
3. 3
   Otrothe solvent was evaporated under reduced pressure
4. 4
   workup.DISSOLUTIONThe so-obtained oily residue (30 g) was dissolved in 160 ml of anhydrous ethanol
5. 5
   workup.ADDITIONAfter addition of an excess of hydrochloric acid ether solution
6. 6
   Otrothe dihydrochloride crystallises

Procedimiento

A solution of 11.4 g (0.1 mole) of 2-chloropyrimidine and 23.2 g (0.1 mole) of 1-(6-benzodioxinyl methyl)piperazine (oil) in 500 ml of pentanol, as refluxed for 6 hours, in the presence of 13.8 g (0.1 mole) of potassium carbonate. After the completion of the reaction, the so-formed salt was filtered off and the solvent was evaporated under reduced pressure. The so-obtained oily residue (30 g) was dissolved in 160 ml of anhydrous ethanol. After addition of an excess of hydrochloric acid ether solution, the dihydrochloride crystallises. 30 g of 1-(benzodioxin-6-yl methyl)-4-(pyrimidin-2-yl)piperazine dihydrochloride white crystals were finally obtained, melting at 215°-220° C.

Fuente