Reacción #93400

Ecuación de reacción

sulfuric acid

2-mercaptobenzothiazole

maleic anhydride

water

→

benzothiazol-2-ylthiosuccinic acid

Rendimiento 87.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITAfter a further hour at 50°
2. 2
   Filtraciónthe precipitated product is filtered off
3. 3
   workup.DISSOLUTIONdissolved in dilute sodium hydroxide solution
4. 4
   FiltraciónThe solution is filtered
5. 5
   FiltraciónThe precipitate is filtered off
6. 6
   Otrodried at 60° in vacuo

Procedimiento

16.8 g of finely powdered 2-mercaptobenzothiazole are suspended in 40 ml of 70% sulfuric acid, and 10.2 g of powdered maleic anhydride are added at 48°-51° in the course of 1 hour, with stirring. After a further hour at 50°, the reaction mixture is cooled to room temperature and is diluted by dropwise addition of 250 ml of water at 25°-35°. After 1 hour, the precipitated product is filtered off and dissolved in dilute sodium hydroxide solution. The solution is filtered and the filtrate is acidified with hydrochloric acid. The precipitate is filtered off and dried at 60° in vacuo. 24.7 g (87% of theory) of benzothiazol-2-ylthiosuccinic acid of melting point 175°-176°, with decomposition, are thus obtained.

Fuente