Reacción #932494

Ecuación de reacción

methanol

1-(3-methanesulfinylphenyl)-3-methyl-2,6-diphenyl-4(1H)-pyridinone

Oxone

→

1-(3-methanesulfonylphenyl)-3-methyl-2,6-diphenyl-4(1H)-pyridinone

Rendimiento 74.1%

Disolventes

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónfollowed by extraction with chloroform
2. 2
   LavadoThe organic layer was washed with water
3. 3
   Secadowas thereafter dried over anhydrous sodium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off
5. 5
   Otrothe residue was crystallized form a 2:1 mixed solvent of acetone and hexane

Procedimiento

In 5 ml of water was dissolved 1.2 g (0.0019 mole) of Oxone. The resulting solution was then added dropwise to 5 ml of a methanol solution of 0.5 g (0.0013 mole) of 1-(3-methanesulfinylphenyl)-3-methyl-2,6-diphenyl-4(1H)-pyridinone. After stirring the reaction mixture for 2 hours, it was poured into water, followed by extraction with chloroform. The organic layer was washed with water and was thereafter dried over anhydrous sodium sulfate. The solvent was distilled off and the residue was crystallized form a 2:1 mixed solvent of acetone and hexane, affording 0.4 g of 1-(3-methanesulfonylphenyl)-3-methyl-2,6-diphenyl-4(1H)-pyridinone having a melting point of 246°-248° C.

Fuente