Reacción #93096

Ecuación de reacción

Nα -[(S)-2-azetidinone-4-carbonyl]-L-histidyl-L-proline benzyl ester

compound ( 12 )

Nα -[(S)-2-azetidinone-4-carbonyl]-L-histidyl-L-proline benzyl ester

→

Nα -[(S)-2-azetidinone-4-carbonyl]-L-histidyl-L-proline

Rendimiento 99.7%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónWhen the catalyst was filtered off
2. 2
   Concentraciónthe filtrate was concentrated

Procedimiento

In 150 ml of methanol was dissolved 782 mg of Nα -[(S)-2-azetidinone-4-carbonyl]-L-histidyl-L-proline benzyl ester (12) and the compound (12) was hydrogenated for 2 hours at room temperature using 156 mg of 10% palladium-carbon as a catalyst. When the catalyst was filtered off and the filtrate was concentrated, 620 mg of Nα -[(S)-2-azetidinone-4-carbonyl]-L-histidyl-L-proline (13) was obtained.

Fuente