Reacción #92972

Ecuación de reacción

1,4-dichloro-2-butanol

m-trifluoromethylphenol

potassium hydroxide

→

4-Chloro-1-(3-trifluoromethylphenoxy)-2-butanol

Disolventes

water

water

isopropanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe resulting reaction mixture
2. 2
   Extracciónextracted with 400 ml
3. 3
   ExtracciónThe ether extract
4. 4
   Lavadowas washed with 0.5N sodium hydroxide
5. 5
   Secadowith water, dried over sodium sulfate
6. 6
   workup.DISTILLATIONdistilled under reduced pressure
7. 7
   workup.DISTILLATIONThe distillate which was collected at 120°-124° C./0.01 mm
8. 8
   Otrosolidified at room temperature

Procedimiento

To a mixture of 0.5 mole (75 g.) of m-trifluoromethylphenol, 1 mole (56 g.) of potassium hydroxide, 100 ml. of water and 400 ml. of isopropanol was added 0.6 mole (84 g.) of 1,4-dichloro-2-butanol with stirring at temperature below 55° C. The resulting reaction mixture was heated at 65° C. for 20 hr., mixed with 2 liters of water, and extracted with 400 ml. of isopropyl ether. The ether extract was washed with 0.5N sodium hydroxide and then with water, dried over sodium sulfate and distilled under reduced pressure. The distillate which was collected at 120°-124° C./0.01 mm. solidified at room temperature and melted at 50°-52° C.

Fuente