Reacción #92971

Ecuación de reacción

1,4-dichloro-2-butanol

4-phenylphenol

sodium hydroxide

→

4-Chloro-(4-biphenylyloxy)-2-butanol

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resulting mixture was heated at 68° C. in a steam bath for 6 hr
2. 2
   Temperatura, cooled
3. 3
   Extracciónextracted with 300 ml
4. 4
   ExtracciónThe chloroform extract
5. 5
   Lavadowas washed with water to neutrality
6. 6
   Secadodried over sodium sulfate
7. 7
   Concentraciónconcentrated to dryness
8. 8
   OtroThe solid residue was recrystallized with isopropanol
9. 9
   Otroyielded 180 g

Procedimiento

To a solution of 1 mole (158 g.) of 4-phenylphenol 100 g. of sodium hydroxide and 500 ml. of water was added 1 mole (143.02 g.) of 1,4-dichloro-2-butanol with stirring at 40° C. The resulting mixture was heated at 68° C. in a steam bath for 6 hr., cooled and extracted with 300 ml. of chloroform. The chloroform extract was washed with water to neutrality, dried over sodium sulfate and concentrated to dryness. The solid residue was recrystallized with isopropanol and yielded 180 g. of a white crystalline solid which melted at 123°-124° C.

Fuente