Reacción #92966

Ecuación de reacción

1,4-dichloro-2-butanol

2-chlorophenol

potassium hydroxide

water

→

4-Chloro-1-(2-chlorophenoxy)-2-butanol

Disolventes

isopropanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONTo a mixture of 129 g
2. 2
   TemperaturaThe resulting mixture was heated in a steam bath at 65° C. overnight
3. 3
   Extracciónextracted with 300 ml
4. 4
   ExtracciónThe ether extract
5. 5
   Lavadowas washed successively with 1N sodium hydroxide, water
6. 6
   Secadodried over sodium sulfate
7. 7
   ConcentraciónThe dried ether solution was concentrated
8. 8
   workup.DISTILLATIONthe oily residue was distilled under reduced pressure
9. 9
   Otroyielding 152 g

Procedimiento

To a mixture of 129 g. (1 mole) of 2-chlorophenol, 60 g. of potassium hydroxide, 100 ml. of water and 400 ml. of isopropanol was added 1.3 moles (185.9 g.) of 1,4-dichloro-2-butanol with stirring at 50° C. The resulting mixture was heated in a steam bath at 65° C. overnight and extracted with 300 ml. of isopropyl ether. The ether extract was washed successively with 1N sodium hydroxide, water and dried over sodium sulfate. The dried ether solution was concentrated and the oily residue was distilled under reduced pressure yielding 152 g. of an oily substance (b.p. 130°-131° C./0.01 mm.).

Fuente