Reacción #929

Ecuación de reacción

2,6-dinitrobenzonitrile

thiophenol

K2CO3

Pyridine

→

2-nitro-6-(phenylthio)benzonitrile

Rendimiento 89.0%

Disolventes

H2O

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe yellow precipitate was collected by filtration
2. 2
   Lavadowashed with 1N NaOH, water
3. 3
   Otrodried

Procedimiento

An ice water bath-cooled mixture of 2.0 g (0.01 mol) of 2,6-dinitrobenzonitrile (Lancaster Synthesis, Inc., Windham, N.H. 03087), 1.06 ml (0.01 mol) of thiophenol, and 1.44 g (0.01 mol) of anhydrous K2CO3 in 50 mL of DMF was stirred for 0.5 h. Pyridine was added to the reaction mixture until it became basic, and was followed by the addition of approximately 100 mL of H2O. The yellow precipitate was collected by filtration, washed with 1N NaOH, water and dried to give 1.94 g (89%) of 2-nitro-6-(phenylthio)benzonitrile as a yellow solid: mp 106°-107° C.

Fuente